Hypertension medicines Antidepressants Diagnosis or medication for hyperlipidemia Thiazide diuretics Overall health behaviors and health solutions utilization, PSA screen (men only) Mammography (ladies only) All-cause hospitalization 27.8 36.7 14.5 2.six 9.2 ten.25.0 34.1 15.five 1.four 8.6 eight.25.0 47.five 12.five 1.3 1.three eight.29.four 43.six 15.2 3.3 five.7 8.8.0 89.5 two.5 1.9 25 (17, 37)5.0 91.4 three.6 1.8 25 (18, 38)five.0 93.eight 1.two 1.3 28 (17, 40)10.0 86.7 3.3 2.four 25 (18,35)41.1 44.9 14.0 29.0 26.4 76.1 54.eight 41.0 11.7 20.32.3 48.six 19.1 31.eight 25.0 76.4 52.3 42.7 10.9 23.40.0 40.0 20.0 28.9 33.8 78.9 55.0 41.three 11.3 26.31.3 49.eight 19.0 34.1 29.9 86.3 50.two 44.6 9.five 20.25.1 17.25.5 23.15.eight 11.19.6 13.Ann Rheum Dis. Author manuscript; available in PMC 2016 June 01.Yun et al.PageBaseline Qualities Exact same TNF 0-1 hospitalization 2 hospitalizations three hospitalizations Outpatient infection Long-term care Receiving Medicare for factors besides age (e.g., disabled), Proportion of biologic exposure considering the fact that drug initiation, 0-6 months given that drug initiation 6-12 months since drug initiation 12-18 months due to the fact drug initiation 64 27 9 59.7 25.eight 14.5 74.six two.5 48.Biologic Exposure throughout Follow-up Abatacept 56.six 27.6 15.8 77.2 1.8 48.4 Rituximab 62.0 22.two 15.eight 79.8 1.four 50.1 Distinctive TNF 56.0 27.4 16.six 68.5 1.0 65.three Author Manuscript Author Manuscript Author Manuscript Author Manuscript73 2577 2275 21Except for the proportion of exposure time considering the fact that drug initiation on the final row, all other components had been measured inside the 6 month baseline before the index hospitalization discharge date. Various TNF refers to a various anti-TNF therapy than the one particular that patients had been utilizing in the time of the index hospitalization; very same TNF refers to re-starting precisely the same anti-TNF therapy that the sufferers have been making use of in the time from the index hospitalization. Median (Interquartile Variety)Imply (standard deviation)Measured during stick to up based upon time since drug initiation.Ann Rheum Dis. Author manuscript; offered in PMC 2016 June 01.TableNumber of events, incidence rates and adjusted HRs for subsequent hospitalized infection by biologic DMARDS.M-CSF, Mouse Events 126 94 2446 7068 34.Peroxiredoxin-2/PRDX2 Protein Biological Activity 6 1.0 (ref) 1.0 (ref) 273 34.four 0.96(0.76,1.19) 1.10(0.89,1.35) 466 27.1 0.96(0.80,1.16) 0.86(0.72,1.03) PY IR per one hundred PY Crude HR (95 CI) Adjusted HR (95 CI)Yun et al.Exposure GroupSwitched to a non anti-TNF biologic Switched to distinct anti-TNF Re-started the identical anti-TNFAbbreviations: HR = Hazard Ratio; IR = incidence rate; Particular person yearsDifferent TNF refers to a various anti-TNF therapy than the one that patients have been working with at the time of the index hospitalization; exact same TNF refers to re-starting the identical anti-TNF therapy that the patients were working with at the time of the index hospitalization.PMID:25558565 Ann Rheum Dis. Author manuscript; obtainable in PMC 2016 June 01.Adjusted for the decile of illness risk score, particular anti-TNF drug at the time of the index hospitalization, steroid use for the duration of baseline, methotrexate use throughout baseline, infection form for the index hospitalization and concurrent medication exposure in the course of follow up.Author ManuscriptPageAuthor ManuscriptAuthor ManuscriptAuthor ManuscriptTableAbsolute incidence rates (IRs) and pairwise comparison of each biologic to every other for subsequent hospitalized infection. Information shown are adjustedYun et al.hazard ratios with 95 self-assurance interval (CI).Referent Group Infliximab 33.8 (1,382/4,087) 34.9 (497/1,423) 36.1 (661/1,831) 28.5 (38/133) 26.5 (88/333) Adalimumab Etanercep.