Foundation, Chennai, in 1994 has produced a significant contribution in this direction.[3] However, only 2 of total kidneys for renal transplantation are DAPK drug procured from deceased renal donors as a consequence of several motives.[4-6] Deceased donor transplant plan in our Camptothecins Accession hospital began in 1998. Within this retrospective study, we highlight our experience in promotion of this program.Materials AND METHODSA retrospective evaluation in the records of 35 deceased donors and 44 renal transplant recipients from August 1998 to April 2011 was done. Of those only 7 DDOT were doneIndian Journal of Urology, Apr-Jun 2013, Vol 29, IssueSwami, et al.: Deceased donor renal transplantation: Our experiancetill 2005. Our DDOT program got accelerated from 2005 onward with cooptation of liver, cardiac, and corneal transplant system as well as a dedicated transplant coordinator in the team. Prior to 2010, one of the two retrieved kidneys was shared with another institute inside the very same city. Following 2010, we’re applying both with the retrieved kidneys in our institute. All recipients were investigated for ESRD by the nephrologists inside the Division of Nephrology and had been then jointly evaluated by the integrated nephrology/urology team of the renal transplant program. Our transplant plan consists of expanded criteria donors (ECDs) for renal transplantation. ECDs have been defined as per the United Network for Organ Sharing (UNOS). All donors older than 60 years or donors between 50 and 59 years with any two on the following have been incorporated: Hypertension, cerebrovascular bring about of brain death, or preretrieval serum creatinine (SCr) 1.five mg/dl.[7-9] All donors and recipients were ABO compatible, and all recipients had a damaging donor T-cell cross-match. The donors have been optimized inside the ICU under the supervision of an intensivist. Organs have been harvested on availability and preserved with cold histidine-tryptophan ketoglutarate (HTK) remedy. Transplantation was carried out as per typical methods. We routinely use DJ stent in our individuals. All recipients received sequential triple drug immunosuppression and induction with rabbit antithymocyte globulin (rATG). Calcineurin inhibitors have been began on engraftment. Induction was commenced with steroid and rATG at a dose of 1.five mg/kg. The first dose of rATG was offered intraoperatively and subsequent rATG infusions had been administered every day to get a minimum of 5 and maximum of 7 doses depending on initial graft function. Maintenance immunosuppression consisted of tapering doses of steroids, mycophenolate mofetil (MMF), and tacrolimus (TAC). The administration of TAC was delayed till the patient had exhibited a brisk diuresis and a declining SCr level (4.0 mg/dl). All patients received surgical web site prophylaxis having a third-generation cephalosporin for 72 h, starting just ahead of the induction of anesthesia. Delayed graft function (DGF) was defined as a failure to decrease the SCr inside 72 h or possibly a requirement for dialysis within the initial week immediately after transplantation. Prolonged drainage was defined as much more than 50 ml of drainage right after postoperative day 7. Postoperative complications and rejection episodes had been noted. The diagnosis of renal allograft rejection was recommended by a decline in renal function confirmed by ultrasound-guided percutaneous allograft biopsy as per the modified Banff classification.[10,11] Cellular rejections were treated with methyl prednisone (MP) 500 mg ?3-5 doses ?r-ATG 1.5 mg/kg single dose. Humoral rejections were treated with plasmaphere.