stemitanu’, Institute of Oncology, Chisinau, Moldova Background: Thrombotic complications regularly create for the CYP26 Inhibitor review duration of the evolution of hematological malignancies, substantially influencing the prices of morbidity and mortality. Aims: The study objectives have been to identify the functions and evaluate the outcomes of treatment of venous thrombosis in non-Hodgkin lymphoma (NHL). Strategies: We performed a clinical-analytical, descriptive study of 1 case with stage IIA diffuse massive B-cell NHL, which was treated and followed up in the Institute of Oncology amongst 2018020. The patient was a female of 46 years old, with concomitant pathology: Vital hypertension, gr. II, moderate additional danger. Hypertensive heart disease. Grade I obesity. The diagnosis was proved as outlined by the Revised 2017 WHO Classification of Tumors of Hematopoietic and Lymphoid GLUT1 Inhibitor site Tissues by the histopathological and immunohistochemical examinations on the biopsied lymph node and common staging procedures, including CT scan. Final results: 3 adjusted cycles of R-CHOP chemotherapy have been performed for the remission induction around the background of cardiotropic and antiplatelet medication, with optimistic clinical-imaging dynamics and devoid of unwanted side effects. Taking into account the persistence of residual tumor lymphadenopathy, the locoregional radiotherapy (LRT) was initiated at the ilioinguinal lymph nodes. The LRT was temporarily stopped at a dosage of 14 Gy resulting from the look from the clinical indicators of venous thrombosis of the suitable femur and calf. Duplex sonography from the legs veins proved the diagnosis on the acute bilateral grade II phlebothrombosis. The patient responded with the tendency of venous recanalization towards the day-to-day oral antiplatelet and anticoagulant therapy below the control of INR, prothrombin index along with the angiosurgeon follow-up (Figure 2). The patient achieved the LRT, achieved the complete remission and underwent the maintenance Bleo-COP cycles.ABSTRACT837 of|FIGURE 1 Duplex sonography from the inferior limbs veins: phlebothrombosis just before the remedy FIGURE 2 Duplex sonography of the inferior limbs veins under the remedy: tendency to recanalization Conclusions: NHL in association with obesity may possibly be complicated with phlebothrombosis throughout the LRT. The phlebothrombosis regression occurred immediately after the comprehensive remission and under the oral antiplatelet and anticoagulant therapy.PO182|Venous Thromboembolism as the Initial Presentation of Various Myeloma X. Ye Second Affiliated Hospital of Guangzhou Health-related University, Guangzhou, China Background: Many myeloma (MM) is often a form of malignant plasma cell illness which can bring about disturbance in coagulation technique. Cases of coagulopathy triggered by MM and treatment-associated thrombosis happen to be reported. But situations of venous thrombosis because the initially presentation of MM had hardly ever been reported. Aims: To report two cases presented with venous thrombosis or pulmonary embolism (PE) just before they were diagnosed with MM. Techniques: Case 1 was a 45-year-old male patient who was diagnosed intracranial venal sinus thrombosis with cranial MR contrast imaging.838 of|ABSTRACTAnticoagulation therapy partially relieved his situation. four months later, he was diagnosed IgG-type MM. Case 2 was a 28-year-old female who was located to possess portal vein, splenic vein thrombosis and superior mesenteric vein thrombosis and received interventional therapy and anticoagulation therapy. 4 months later, she was diagnoses MM. She had received sp