igure four). Most annotated genes in the Nav1.8 MedChemExpress biological processes category were connected to the inflammatory response and cellular metabolism. DEGs in PPAR supplier comparison group S_Z vs. S_B have been primarily connected with GO terms related to stimulation, biological processes connected with lipid synthesis, and metabolism, which include the lipid/organic substance catabolic approach and the inflammatory/stimulus response. The majority of DEGs in comparison group K_Z vs. K_B have been associated with stimulationrelated biological processes, G-protein coupled receptor activity, signal transduction-related molecular functions, and cellular elements (cytoskeletal part, membrane component, cytoplasm), such as the acute-phase response, G protein-coupled peptide receptor activity, and transmembrane transporter activity. The majority of DEGs in comparison group H_Z vs. H_B had been assigned with biological processes connected with stimulus, cellular processes, and cellular elements, such as cellular response to endogenous stimulus, negative regulation of biological procedure, regulation of principal metabolic approach, and positive regulation of biological procedure. The majority of DEGs in comparison group M_Z vs. M_B have been associated with stimulus, immune method, cellular processes, signal transductionrelated molecular functions, and cellular elements, including response to abiotic stimulus,Animals 2021, 11,9 ofpositive regulation of neutrophil migration, cellular response to interleukin-1, constructive regulation of biological course of action, and intracellular signal transduction. The majority of DEGs in comparison group J_Z vs. J_B have been linked to stimulus, immune course of action, G protein-coupled peptide receptor activity, cellular approach, and cellular elements, which include cellular response to chemical stimulus, G protein-coupled receptor signaling pathway, cellular response to interleukin-1, neutrophil chemotaxis, positive regulation of cellular approach, and cell migration. The majority of DEGs in comparison group Z_Z vs. Z_B have been associated with cell improvement, tissue improvement, cellular approach, and cellular components, for instance striated muscle tissue development, striated muscle cell development, muscle structure improvement, and cell differentiation. Additionally, the analysis identified 9, 21, 25, five, 12, and 1 KEGG pathways that have been significantly enriched in DEGs in comparison groups S_Z vs. S_B, K_Z vs. K_B, H_Z vs. H_B, M_Z vs. M_B, J_Z vs. J_B, and Z_Z vs. Z_B, respectively (Figure 5). The drastically enriched pathways in DEGs from comparison group S_Z vs. S_B mostly incorporated the complement and coagulation cascades and protein digestion and absorption (Figure six). The pathways significantly enriched in DEGs from comparison group K_Z vs. K_B primarily integrated complement and coagulation cascades, IL-17 signaling pathway, and PI3K-Akt signaling pathway. The significantly enriched pathways in DEGs from comparison group H_Z vs. H_B primarily included the complement and coagulation cascades, protein digestion and absorption, PI3K-Akt signaling pathway, MAPK signaling pathway, and NF-kappa B signaling pathway. The pathways that had been drastically enriched in the DEGs from comparison group M_Z vs. M_B mostly incorporated protein digestion and absorption, IL17 signaling pathway, TNF signaling pathway, NF-kappa B signaling pathway, NODlike receptor signaling pathway, and HIF-1 signaling pathway. The pathways that have been significantly enriched in the DEGs from comparison group J_Z vs. J_B primarily included