prevention of HCV entry and infection in cell culture was also reported in ex vivo research (Hossan et al. 2018). In addition, the plant can also be reported for any potent anti-HIV compound and in Ranikhet illness virus (Pandey et al. 2005). In an in silico study, the compound boeravisterol discovered in B. diffusa was evaluated against Mpro and was located to have therapeutic properties against COVID-19 (Rutwick Surya and Praveen 2021). Further, no acute and sub-acute toxicity was reported from B. diffusa root extract at the dose of 200 mg/kg in Wistar rats (Karwasra et al. 2016).Production of white blood cells and weight of your lymphoid organs were also enhanced in the groups that received ten mg/kg nanocurcumin (Afolayan et al. 2018). Curcumin has been reported effective against several enveloped viruses, including respiratory viruses like influenza A and respiratory syncytial virus (Praditya et al. 2019). Curcumin may interfere the entry of variety A influenza virus by its interaction together with the receptor binding region or interfering with viral haemagglutination protein (Ou et al. 2013). The monoacetylcurcumin, a structural analogue of curcumin on Akt phosphorylation, is required for propagation of influenza A virus (Richart et al. 2018). An in vitro study of curcumin reported capability to inhibit gene replication of hepatitis B virus (HBV) by inhibiting cccDNA-bound histone acetylation, and it has the prospective to be created as a cccDNAtargeting antiviral agent for hepatitis B (Wei et al. 2017). Furthermore, a study reported that curcumin inhibits 3CL protease activity in SARS-CoV, an necessary composition for viral replication (Wen et al. 2007). Taking leads from earlier studies, a recent docking study on SARS-CoV-2 reports the potential of curcumin in inhibiting SARS-CoV-2 into lung cells by disrupting the interaction of S protein and ACE2 (Rajagopal et al. 2020; Pandey et al. 2020). This shows the prospective of curcumin inside the disruption of SARS-CoV-2 virus entry and replication which is also associated with all the activation from the nuclear aspect erythroid two elated element two (NRF2) pathway (Thimmulappa et al. 2021). C. longa and its phytoconstituents are found to be secure in a variety of clinical research (T nesen et al. 2002; Maheshwari et al. 2006; Aggarwal et al. 2016; Thimmulappa et al. 2021).Embelia ribes Burm. (Vidang)E. ribes is really a normally employed anthelmintic classic remedy (Bhandari et al. 2002). It’s reported to have antimicrobial, antidiabetic, Adenosine A3 receptor (A3R) Inhibitor supplier antioxidant, S1PR2 custom synthesis anti-inflammatory, analgesic, contraceptive and antipsychotic activity as well as made use of in acute respiratory distress syndrome (Bhandari et al. 2002; Harish et al. 2012; Shirole et al. 2015; Durg et al. 2017). Embelin, the big phytoconstituent of E. ribes, was examined in an in silico molecular docking study. The study showed that the binding web site for embelin is located in the RBD of viral haemagglutinin which may be utilized for the development of a plant-based anti-influenza agent (Bachmetov et al. 2012). Another vital polyphenol present in the plant is quercetin. It truly is reported for diverse antiviral activities against influenza virus (H1N1) and HCV. Quercetin inhibits the HCV NS3 protease and reduces viral production by inhibiting both NS3 and heat shock proteins that are important for HCV replication (Bachmetov et al. 2012). Quercetin is reported for viral step inhibition of internal ribosome entry website translation, NS5A protein levels, HCV replication, HCV production and putative vira