rmaceutical agents which aid in limiting the infectious and non-infectious ailments (Kaushik et al. 2018; Sharma et al. 2021). Substantial studies could present an insight into the future course of analysis for the plausible developmentof successful COVID-19 management. This can be accomplished by the utilization and development of various natural product-based medicines. Various Materia Medica of Ayurveda conceptualize a group of herbs, formulations and therapies for enhancing physique resistance beneath the comprehend term Rasayana. The precise properties possessed by these herbs of Rasayana category are evaluated and validated in different scientific research (Chulet and Pradhan 2009). These botanicals are reported to become wealthy in numerous specialized metabolites responsible for immune modulation, antioxidant activities, neurodegenerative issues and rejuvenators and could act as nutritional supplements (Thakur et al. 2007; Doshi et al. 2013). Right here we give a comprehensive detail on some probable prospective leads from Ayurveda to develop helpful antiviral and/or immunomodulator for prophylactic or adjunct therapy in SARS-CoV-2.MethodologyThe literature search was carried out on two broad dimensions. Initially, the classical text was searched to shortlist the plants followed by advanced search to explore the out there scientific evidences in various search engines like google. Within the classical literature search, an extensive assessment was completed in Charaka Samhita to identify the Rasayana drugs. Charaka Samhita is amongst the oldest, most authentic along with the most broadly practised treatises on Ayurveda. The text in Charaka Samhita is written within the kind of verses or shloka and partly in prose. The compendium comprises 120 chapters categorized into eight sections or Sthana. Each section pertained to a precise subject. Chapters 310 are named as Chikitsa Sthana which consists of 30 chapters that deal with the study of preservation of wellness and prevention and management of various illnesses. The very first chapter in this is on Rasayana that is additional divided into four sub-sections (or sub-chapters). These 4 subsections consist of 129 medicines (Rasayana) within the type of many single and compound herbal and herbo-mineral formulations. Out of those, 63 single or plant-based formulations have herbs and particular metals as a principal ingredient. Upon excluding metals, alkali, von Hippel-Lindau (VHL) Species dietary items and herbs whose identity was not confirmed, the remaining 50 was single herbs. These 50 herbs had been scanned for antiviral and immunomodulator activities. A detailed methodology is presented in Fig. 1. Soon after collection of these 50 herbs, an substantial literature search was performed through different internet databases like Pubmed, ScienceDirect, Scopus and Google Scholar by Boolean info retrieval approach (Pohl et al. 2010; Tewari et al. 2017, 2018). The botanical name of your plants with “AND” operator followed by keyword phrases “antiviral,” “coronavirus,” “covid-19,” “immunomodulatory” and “immunity” was searched. The period of article evaluation was from αvβ8 list theEnviron Sci Pollut Res (2021) 28:55925Fig. 1 Schematic representation of your methodology for shortlisting the Rasayana drugslast 20 years published in English language. Ultimately, 13 herbs were shortlisted fulfilling the criteria of getting possible antiviral and immune modulation activities. A procedure of thorough discussions amongst authors and subject authorities based on their usage, i.e. most generally utilized, recognized safety profiles, much better availability and J