l target–NS3 protease (Gonzalez et al. 2009;Curcuma longa L. (Haridra)C. longa is among one of the most frequently made use of drug in Ayurveda, a frequent spice (Thimmulappa et al. 2021) and colouring agent (Ou et al. 2013). Curcumin, one of many major active principle of C. longa (Li et al. 2019), is reported to inhibit NF-B activation post exposure of several inflammatory stimuli in 117 randomized manage trials. There was a significant reduction in TNF-, IL-6, TGF- and MCP-1 following curcumin supplementation (Panahi et al. 2016). Curcumin inhibits mitogen-stimulated lymphocyte proliferation, IL-2 synthesis/signaling and NF-kB (IL-2 promoter transcription element) activation (Ranjan et al. 2004). On top of that, the macrophage phagocytic activity is also improved by curcumin (Antony et al. 1999). A study exhibited that nanoparticulate curcumin stimulated greater early cell-mediated and humoral immune response with comparable benefits in secondary humoral antibody titres.Environ Sci Pollut Res (2021) 28:55925Shirole et al. 2015). Further, in a study, ethyl acetate extract of fruits of E. ribes has shown very promising PDE11 medchemexpress antiviral activity against influenza virus A/34 (H1N1), with an IC50 of 0.2 g/ mL; also, the study revealed that embelin was most helpful when added at early stages with the viral life cycle (0 h postinfection), as well as, it was discovered productive against avian influenza virus A/84 (H5N2) (Bachmetov et al. 2012). A study has reported that pre-treatment with embelin (five, 10 and 20 mg/kg, i.p.) decreased lung oedema, mononucleated cellular infiltration, nitrate/nitrite, total protein, albumin concentrations, TNF- in the bronchoalveolar lavage fluid and myeloperoxidase activity in lung homogenate. Embelin markedly prevented pO2 down-regulation and pCO2 augmentation. Additionally, it attenuated lung histopathological alterations in acute respiratory distress syndrome model, therefore exhibiting lung safeguarding home and anti-inflammatory activity in lung cell. hence is usually a promising herb in preventing lung damage like complications in COVID-19 (Hossan et al. 2018). A current computational study reports the role of embelin to inhibit the SARS-CoV-2 Mpro protease much more particularly as a consequence of formation of a covalent bond between S (Cys145) and an embelin C (carbonyl). That is additional assisted by two T-type calcium channel Compound protein amino acids N (imidazole-His41) which are in a position to capture H[S(Cys145)] and HN(His163), which donate a proton to embelin O(carbonyl) forming an OH moiety. This final results in inhibition of the viral protease (Caruso et al. 2020). Ayurvedic literature mostly counts the fruits of E. ribes for its effect as antibacterial, antiprotozoal, analgesic, anti-inflammatory, antioxidant and remedy for abdominal issues and lung fungus infections (Dwivedi et al. 2019). This drug has been reported for the therapy of influenza in 1919 (Menon 1919). Respiratory distress is amongst the major symptoms found throughout the second surge of SARS-CoV-2 in India. E. ribes also possesses anti-inflammatory and protective effect against LPS-induced airway inflammation by minimizing nitrosative stress, physiological parameters of blood gas adjust, TNF and mononucleated cellular infiltration, indicating it as a possible therapeutic agent for acute respiratory distress syndrome (Shirole et al. 2015). The drug could be repurposed for the respiratory distress taking place in SARS-CoV-2. Potassium embelate, two,5-dihydroxy, 3-undecyl-1, 4-benzoquinone, derived from E. ribes was tested for subacute, chron