Latelet-derived development element receptor, Platelet-derived growth element receptor, LDLR-related protein 1 Platelet-derived development factor receptor, Platelet-derived development element receptor, Sphingosine-1-phosphate receptor 1 Platelet-derived development element receptor, Platelet-derived development element receptor, Opioid growth element receptor Plexin B2 Protein SR-BI/CD36 Proteins Biological Activity tyrosine phosphatase, receptor type, B Syndecan 1 Syndecan 3 Retinoic acid receptor responder two Reelin Semaphorin 3C Semaphorin 3F Chemokine (C-C motif) receptor-like two Integrin, three Plexin D1 Neuropilin 1 Neuropilin two Semaphorin 4C Semaphorin 6D Secreted frizzledrelated protein 1 Slit homolog two Transforming development factor, 1 Plexin B2 Kinase insert domain receptor Frizzled class receptor six Syndecan 1 Activin A receptor variety II ike 1 CD109 molecule Syndecan 2 Transforming growth issue, receptor 2 (Continued)Table 1. ContinuedGene Pair TGFB1_TGFBR3 TGFB2_ ACVR1 TGFB2_ENG TGFB2_TGFBR2 TGFB2_TGFBR3 TGFB3_TGFBR2 TGFB3_TGFBR3 TNFSF12_ TNFRSF12A TNFSF12_ TNFRSF25 TNFSF13_FAS TNFSF13_SDC2 TNFSF13_ TNFRSF1A VEGFA_SIRPA VEGFA_TYRO3 VEGFC_FLT1 VEGFC_FLT4 VEGFC_ITGB1 VEGFC_KDR VEGFC_LYVE1 VEGFC_NRP2 WNT4_FZD6 Wingless-type MMTV integration web site four Vascular endothelial growth issue C Vascular endothelial growth element A TNF superfamily, member 13 TNF superfamily, member 12 Transforming development element, three Transforming development issue, two Ligand Receptor Transforming growth issue, receptor 3 Activin A receptor, kind I Endoglin Transforming growth aspect, receptor two Transforming development factor, receptor 3 Transforming growth issue, receptor two Transforming growth aspect, receptor three TNF receptor superfamily, member 12A TNF receptor superfamily, member 25 Fas cell surface death receptor Syndecan 2 TNF receptor superfamily, member 1A Signal-regulatory protein TYRO3 protein tyrosine kinase Fms-related tyrosine kinase 1 Fms-related tyrosine kinase 4 Integrin, 1 Kinase insert domain receptor Lymphatic vessel endothelial hyaluronan rec 1 Neuropilin two Frizzled class receptorPTN_SDC1 PTN_SDC3 RARRES2_ CCRL2 RELN_ITGA3 SEMA3C_ PLXND1 SEMA3F_NRP1 SEMA3F_NRP2 SEMA4C_ PLXNB2 SEMA6D_KDR SFRP1_FZD6 SLIT2_SDC1 TGFB1_ ACVRL1 TGFB1_CD109 TGFB1_SDC2 TGFB1_TGFBRThis table is limited to signaling proteins, cytokines, growth things, and chemokines. For other cell-surface ligand-receptor pairs, we refer to Information S1. BMP indicates bone morphogenetic protein; CD, cluster of differentiation; EGF, epidermal development factor; LDLR, low-density lipoprotein receptor; MMTV, mouse mammary tumor virus; PDGF, platelet-derived development element; TEK, endothelial tyrosine kinase; TK, tyrosine kinase; TNF, tumor necrosis element; TYRO, tyrosine-protein kinase receptor; and Wnt, wingless-type integration website household, member 1.one more ten are expressed by each cardiomyocytes and fibroblasts (Table S3); just 4 are expressed especially by cardiomyocytes. If 1 considers not simply the ligands but the complete 79 ligand-receptor pairs expressed by cardiomyocytes, 31 are expressed by all 3 cell forms and an additional 36 are expressed by both cardiomyocytes and fibroblasts; just 9 are expressed especially by cardiomyocytes. What is also fascinating is that most ligands expressed by all 3 cellJ Am Heart Assoc. 2021;ten:e019169. DOI: ten.1161/JAHA.120.Segers et alAutocrine Signaling in the Nectin-1/CD111 Proteins Biological Activity HeartTable 2. Ligands Expressed by Cardiomyocytes, Endothelial Cells, and FibroblastsGene ADM ANGPT2 ANXA1 CTGF CXCL12 CYR61 DKK1 GAS6 HGF IGF2 JAG1 MDK NPPB PDAP1 PDG.