Product Name :
ML786 dihydrochloride
Description:
ML786 dihydrochloride is a potent and orally bioavailable Raf inhibitor, with IC50s of 2.1, 4.2, and 2.5 nM for V600EΔB-Raf, wt B-Raf, and C-Raf, respectively. ML786 dihydrochloride also inhibits Abl-1, DDR2, EPHA2, KDR, and RET (IC50=<0.5, 7.0, 11, 6.2, 0.8 nM). ML786 dihydrochloride can be used for the research of cancers.
CAS:
1237536-18-3
Molecular Weight:
611.48
Formula:
C29H31Cl2F3N4O3
Chemical Name:
(Z)-3-(2-aminopropan-2-yl)-N-[(2R)-7-[(7-hydroxy-5,6-dihydro-1,8-naphthyridin-4-yl)oxy]-1,2,3,4-tetrahydronaphthalen-2-yl]-5-(trifluoromethyl)benzene-1-carboximidic acid dihydrochloride
Smiles :
Cl.Cl.CC(C)(N)C1C=C(C=C(C=1)C(F)(F)F)/C(/O)=N/[C@H]1CC2=CC(=CC=C2CC1)OC1C=CN=C2N=C(O)CCC=12
InChiKey:
DNMWHXHMDZCGEX-GHVWMZMZSA-N
InChi :
InChI=1S/C29H29F3N4O3.2ClH/c1-28(2,33)19-11-18(12-20(15-19)29(30,31)32)27(38)35-21-5-3-16-4-6-22(14-17(16)13-21)39-24-9-10-34-26-23(24)7-8-25(37)36-26;;/h4,6,9-12,14-15,21H,3,5,7-8,13,33H2,1-2H3,(H,35,38)(H,34,36,37);2*1H/t21-;;/m1../s1
Purity:
≥98% (or refer to the Certificate of Analysis)
Shipping Condition:
Shipped under ambient temperature as non-hazardous chemical or refer to Certificate of Analysis
Storage Condition :
Dry, dark and -20 oC for 1 year or refer to the Certificate of Analysis.Metformin Purity & Documentation
Shelf Life:
≥12 months if stored properly.
Stock Solution Storage:
0 – 4 oC for 1 month or refer to the Certificate of Analysis.Camrelizumab supplier
Additional information:
ML786 dihydrochloride is a potent and orally bioavailable Raf inhibitor, with IC50s of 2.PMID:32924706 1, 4.2, and 2.5 nM for V600EΔB-Raf, wt B-Raf, and C-Raf, respectively. ML786 dihydrochloride also inhibits Abl-1, DDR2, EPHA2, KDR, and RET (IC50=Product information|CAS Number: 1237536-18-3|Molecular Weight: 611.48|Formula: C29H31Cl2F3N4O3|Chemical Name: (Z)-3-(2-aminopropan-2-yl)-N-[(2R)-7-[(7-hydroxy-5,6-dihydro-1,8-naphthyridin-4-yl)oxy]-1,2,3,4-tetrahydronaphthalen-2-yl]-5-(trifluoromethyl)benzene-1-carboximidic acid dihydrochloride|Smiles: Cl.Cl.CC(C)(N)C1C=C(C=C(C=1)C(F)(F)F)/C(/O)=N/[C@H]1CC2=CC(=CC=C2CC1)OC1C=CN=C2N=C(O)CCC=12|InChiKey: DNMWHXHMDZCGEX-GHVWMZMZSA-N|InChi: InChI=1S/C29H29F3N4O3.2ClH/c1-28(2,33)19-11-18(12-20(15-19)29(30,31)32)27(38)35-21-5-3-16-4-6-22(14-17(16)13-21)39-24-9-10-34-26-23(24)7-8-25(37)36-26;;/h4,6,9-12,14-15,21H,3,5,7-8,13,33H2,1-2H3,(H,35,38)(H,34,36,37);2*1H/t21-;;/m1../s1|Technical Data|Appearance: Solid Power|Purity: ≥98% (or refer to the Certificate of Analysis)|Shipping Condition: Shipped under ambient temperature as non-hazardous chemical or refer to Certificate of Analysis|Storage Condition: Dry, dark and -20 oC for 1 year or refer to the Certificate of Analysis.|Shelf Life: ≥12 months if stored properly.|Stock Solution Storage: 0 – 4 oC for 1 month or refer to the Certificate of Analysis.|Drug Formulation: To be determined|HS Tariff Code: 382200|How to use|In Vitro:|ML786 (3 h) inhibits the kinase phosphorylation of extracellular signal-regulated kinase (ERK) (pERK) in A375 cells, with an IC50 of 60 nM.|In Vivo:|ML786 (75 mg/kg; p.o. once daily for 21 d) inhibits the subcutaneous A375 M xenografts in immunocompromised mice. ML786 (75 mg/kg; a single p.o.) strongly inhibits the Raf pathway in mice. ML786 (10 mg/kg; p.o.) exhibits oral bioavailability of 85% and AUC1-24h of 35.9 μM·h in rats. ML786 (1 mg/kg; i.v.) exhibits plasma clearance of 0.44 L/h/kg and Vss of 3.93 L/kg in rats.|Products are for research use only. Not for human use.|