Human NKp46/NCR1/CD335 Protein 5126

Additional Information:
accession O76036|express systemHEK293|product tagC-hFc|purity> 95% as determined by Tris-Bis PAGE;> 95% as determined by HPLC|backgroundNKp46, along with NKp30 and NKp44, are activating receptors that have been collectively termed the natural cytotoxicity receptors (NCR).These receptors lack significant sequence homology to one another. They are expressed almost exclusively by NK cells and play a major role in triggering some of the key lytic activities of NK cells.|molecular weightThe protein has a predicted MW of 53.2 kDa. Due to glycosylation, the protein migrates to 68-70 kDa based on Tris-Bis PAGE result.|available size100 g, 500 g|endotoxinLess than 1EU per g by the LAL method.|Human NKp46/NCR1/CD335 Protein 5126proteinSize and concentration100, 500g and lyophilizedFormLyophilizedStorage InstructionsValid for 12 months from date of receipt when stored at -80C. Recommend to aliquot the protein into smaller quantities for optimal storage. Please minimize freeze-thaw cycles.Storage bufferShipped at ambient temperature.Purity> 95% as determined by Tris-Bis PAGEtarget relevanceNKp46, along with NKp30 and NKp44, are activating receptors that have been collectively termed the natural cytotoxicity receptors (NCR).These receptors lack significant sequence homology to one another. They are expressed almost exclusively by NK cells and play a major role in triggering some of the key lytic activities of NK cells.Protein namesNatural cytotoxicity triggering receptor 1 (Lymphocyte antigen 94 homolog) (NK cell-activating receptor) (Natural killer cell p46-related protein) (NK-p46) (NKp46) (hNKp46) (CD antigen CD335)Gene namesNCR1,NCR1 LY94Protein familyNatural cytotoxicity receptor (NCR) familyMass9606DaFunctionCytotoxicity-activating receptor that may contribute to the increased efficiency of activated natural killer (NK) cells to mediate tumor cell lysis.Subellular locationCell membrane ; Single-pass type I membrane protein .TissuesSelectively expressed by both resting and activated NK cells.StructureInteracts with CD247 and FCER1G.Post-translational modificationN-glycosylated.; O-glycosylated.Target Relevance information above includes information from UniProt accession: O76036The UniProt Consortium|